Download and install the latest version of graphviz.

Download and unpack the latest version of pygraphviz.

Update the library_path and include_path in setup.py.

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library_path='/usr/local/lib/graphviz/'
include_path='/usr/local/include/graphviz/'

Install as usual:

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$ sudo python setup.py install

Test the install.

Important: Before you enter the python interpreter, make sure you leave the pygraphviz directory.

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$ cd ~
$ python
>>> import pygraphviz
>>>

Sources:

http://bradmontgomery.blogspot.com/2010/07/pygraphviz-on-os-x-sl-with-virtualenv.html